One thing that is very different among Humbucker & Single coil combinations is that the impedance on the single coil is usually less, so you'll either have one over powering the other or a decrease in output when mixed together. Fender and other manufacturers usually put a resistor in place when they are mixed (you may already have the resistor installed if its a stock fat strat. Or you can just choose not to blend them.
I'm of the other camp, I prefer the twang of a single coil in the bridge position and the fatness of a humbucker in the neck....particularly on a tele. On strats, I like to blend the 1-3 and 3-5 positions for cool rhythm and blues/funk tones with all single coils.
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